CACTUS: INTEGRATING CLONAL ARCHITECTURE WITH GENOMIC CLUSTERING AND TRANSCRIPTOME PROFILING OF SINGLE TUMOR CELLS

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity.Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.The confidence of the cell-to-clone mapping can b

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Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue Regeneration

Extracellular vesicles (EVs) are heterogeneous populations of nano- and micro-sized vesicles secreted by various cell types.There is mounting evidence that EVs have widespread roles in transporting proteins, 2005 honda accord intake manifold lipids, and nucleic acids between cells and serve as mediators of intercellular communication.EVs secreted f

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Immunoinformatics aided-design of novel multi-epitope based peptide vaccine against Hendra henipavirus through proteome exploration

Hendra henipavirus (HeV) is an emerging zoonotic bat-borne paramyxovirus that is capable of causing severe public health complications in humans.It promotes both respiratory and neurological disorders in airbrush graphic tee humans as well as in horses.Currently, there are no therapeutics or vaccines available against the deadly HeV.We aimed to des

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